Prediction Napoli vs Pisa 2025/2026 – Betting Tips for the Serie A on 22/09/2025

Match preview

Napoli return to the Stadio Diego Armando Maradona with momentum and a clear mandate: keep the perfect start to the Serie A season rolling. The hosts sit atop the table after three league outings, boasting three wins, six goals scored and just one conceded. Their late-summer schedule has been productive — victories over Fiorentina, Cagliari and Sassuolo have painted a picture of a team in control domestically, even as they were undone by Manchester City in midweek’s Champions League fixture. That 2-0 loss in Europe should only sharpen Napoli’s focus for this fixture; Valerio Crezzini will preside over a crowd of up to 60,240 in Napoli’s back yard, where the home side’s attacking averages and shot volume have dominated recent encounters.

Form and recent tests

Pisa present a stark contrast. Sitting 18th with a solitary point from three matches, their league form has been fragile: narrow defeats to Roma and Udinese and a draw at Atalanta are peppered with mixed results in preseason and cup action. Pisa’s underlying numbers tell a story of limited firepower — only one goal across their league matches and a lack of clean sheets. Their travels to Naples will force them to contend with a side averaging a higher number of attacks and far more dangerous entries into the opposition box.

Tactical matchup and likely tone

Expect a game dominated by Napoli’s rhythm. Home statistics underline their intent: a higher volume of shots and shots on target, healthy averages for corners and dangerous attacks. Pisa will be compact, pragmatic, and look to smother spaces and avoid opening themselves up to the hosts’ potency. Given Napoli’s recent run of clean sheets and defensive solidity, combined with Pisa’s struggles to score, the contest looks likely to unfold with Napoli pressing control and Pisa aiming to frustrate rather than outscore.

Edge and context

Context matters: Napoli come off a high-level European test that exposed areas to refine, while Pisa’s morale may be fragile after the narrow league loss to Udinese. The bookmakers mirror this gulf — the market places a substantial probability on a home win at Stadio Diego Armando Maradona, reflecting both form and venue advantage.

Betting suggestion: Back Napoli to win (1) in the 1X2 market. The home side’s form, superior attacking and defensive numbers, and the market pricing all point to a Napoli victory as the most likely outcome.